Multifunctional fluorescent Off-On-Off nanosensor for Au3+ and S2-employing N-S co-doped carbon-dots

Out of the plethora of sensors being developed using carbon dots, the use of green alternatives with the potential of multi-functionality is still in its infancy. In view of this, the present work shows the use of Rosa indica derived heteroatom i.e. nitrogen and sulfur co-doped rose carbon dot (N-S@RCD) for dual fluorescence based sensing of multi-analytes. The N-S@RCD shows interesting fluorescence turn off-on-off response towards S2- and Au3+ with limit of detection (LOD) 92.4 nM and 63.1 nM, respectively. To the best of our knowledge, this is first report on direct Turn-on of c-dots with S2- ions without any intermediate c-dot-quencher complex. Further, the bioimaging and flow cytometry studies revealed the potential of live cell imaging, intracellular sensing and cytocompatibility of N-S@RCD. The hemo-compatibility of N-S@RCD was also investigated for potential in vivo applications. Moreover, the off-onoff fluorescence behaviour was used to construct molecular logic gates which simulate single input logic YES and multi-input INHIBIT logic system. (C) 2018 Elsevier Ltd. All rights reserved.