Andirolides W-Y from the flower oil of andiroba (Carapa guianensis, Meliaceae)

Three new limonoids, andirolides W-Y (1-3), were isolated from the flower oil of Carapa guianasis AUBLET (Meliaceae). Their structures were elucidated on the basis of spectroscopic analyses using 1D and 2D NMR spectra and FABMS. Seven known limonoids: 7-deacetoxy-7-oxogedunin (4), 6 alpha-acetoxygedunin (5), methylangolensate (6), 6 alpha-hydroxygedunin (7), 6 alpha-acetoxy-7 alpha-deacetoxy7 alpha-hydroxygedunin (8), gedunin (9), and 7-deacetoxy-7-hydroxygedunin (10) from this flower oil were evaluated for the effects on the production of NO in LPS-activated mouse peritoneal macrophages. (C) 2014 Published by Elsevier B.V.