期刊
FITOTERAPIA
卷 103, 期 -, 页码 277-282出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.04.016
关键词
Mangrove plant; Ceriops tagal; Diterpenes; Tagalenes; Antitumor activities
资金
- Sino-German Project [GZ816]
- NSFC [30672607]
- National Hi-Tech 863-Projects [2010DFA31610, 2011M090701, 2013AA092902]
Chemical examination of the barks of mangrove plant Ceriops tagal resulted in the isolation of six new dolabrane-type diterpenes with the trivial names of tagalenes A-F (1-6), together with 10 known analogues. The structures of new compounds were elucidated by extensive spectroscopic data analyses. Tagalenes A-C (1-3) are characterized by 18-nordolabrane scaffold, while tagalene F (6) featured by a 2,3-seco dolabrane derivative. Antitumor assay revealed that seven compounds exhibited potent inhibitory effects against a panel of tumor cell lines with IC50 < 10 mu M, while tagalsin C (8) exerted the most potent activities in comparison with the IC50 values of the rest compounds. The primary structure-activity relationship is discussed. Tagalsin C also exerted the potent effects against a panel of drug-resistant human tumor cell lines, indicating it to be a promising molecule for further evaluation as an antitumor lead compound. (C) 2015 Elsevier B.V. All rights reserved.
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