期刊
CARBON
卷 130, 期 -, 页码 416-423出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2018.01.026
关键词
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资金
- National Natural Science Foundation of China [11674085, 51402095, 21375033]
- Natural Science Fund for Creative Research Groups of Hubei Province of China [2011CDA111, 2014CFA015]
- Natural Science Foundation of Hubei Province [2015CFA124]
- Program for Excellent Youth Scholars of Innovative Research Team by Hubei Provincial Department of Education [T201101]
Here, an electrochemiluminescent aptasensor based on beta-cyclodextrin/graphitic carbon nitride (beta-CD/g-C3N4) composite for selective and highly ultrasensitive assay of platelet derived growth factor BB (PDGF-BB) is fabricated. To achieve the sensitive and specific detection of PDGF-BB, it is an available strategy to explore excellent electrochemiluminescent (ECL) luminophores with the advantages of high electrochemical-driven luminescent activity and a specific recognition function. In this work, for the first time a novel beta-CD non-covalently functionalized g-C3N4 composite beta-CD/g-C3N4 was employed to construct the ECL detection platform for PDGF-BB based on its aptamer. The limit of detection was determined to be as low as 2.6 x 10(-13) g/mL. It was observed that beta-CD was playing a key role in improving the adamantane-labeled DNA amount modified on the electrode surface. It can further help to amplify the ECL quenching effect by both energy transfer and photo-excited electron transfer processes between g-C3N4 emitter and ferrocene quencher. It is anticipated that beta-CD/g-C3N4 may be a class of promising material for constructing ECL sensors. (c) 2018 Elsevier Ltd. All rights reserved.
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