期刊
CARBOHYDRATE POLYMERS
卷 197, 期 -, 页码 478-489出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.06.023
关键词
Atopic dermatitis; Tacrolimus; Hyaluronic acid; Nanoparticles; Efficient dermal targeting; Improved anti-dermatitis efficacy
资金
- Institute of Research Management & Innovation (IRMI), Universiti Teknologi MARA (UiTM) [600-IRMI/DANA 5/3/LESTARI (0007/2016)]
Nano-delivery systems have gained remarkable recognition for targeted delivery of therapeutic payload, reduced off-target effects, and improved biopharmaceutical profiles of drugs. Therefore, we aimed to fabricate polymeric nanoparticles (NPs) to deliver tacrolimus (TCS) to deeper layers of the skin in order to alleviate its systemic toxicity and improved therapeutic efficacy against atopic dermatitis (AD). To further optimize the targeting efficiency, TCS-loaded NPs were coated with hyaluronic acid (HA). Following the various physicochemical optimizations, the prepared HA-TCS-CS-NPs were tested for in vitro drug release kinetics, drug permeation across the stratum corneum, percentage of drug retained in the epidermis and dermis, and anti-AD efficacy. Results revealed that HA-TCS-CS-NPs exhibit sustained release profile, promising drug permeation ability, improved skin retention, and pronounced anti-AD efficacy. Conclusively, we anticipated that HA-based modification of TCS-CS-NPs could be a promising therapeutic approach for rationalized management of AD, particularly in children as well as in adults having steroid phobia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据