期刊
CARBOHYDRATE POLYMERS
卷 197, 期 -, 页码 117-127出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.05.071
关键词
Halloysite nanotubes; Chitosane oligosaccharides; Drug delivery; Magnetic targeting
资金
- Independent innovation fund project of agricultural science and technology of Jiangsu Province [CX(17)1003]
- Guizhou Provincial Science and Technology Department Joint Fund Project [7076]
- China Scholarship Consul (CSC) grant [2013012007]
In this research, to achieve enhanced intracellular uptake of anticancer drug carriers for efficient chemotherapy, folic acid conjugated chitosan oligosaccharides assembled magnetic halloysite nanotubes (FA-COS/MHNTs) have been tailored as multitask drug delivery system towards camptothecin (CPT). Besides magnetic targeting, the nanocomposites have been reacted with folate complex in order to selectively target cancer cells over expressing the folic acid receptor. HNTs showed to have a high storage capacity of CPT. In vitro, the release results indicated that CPT outflow from the nanocarriers at pH 5 was much greater than that at both pH 6.8 and 7.4. MTT assays showed that the CPT-loaded nanocarriers exhibited stronger cell growth inhibitory against colon cancer cell. Furthermore, nanocarriers gained specificity to target cancer cells because of the enhanced cell uptake mediated by FA moiety and presence of COS. Therefore, the rational designed HNTs nanocarrier for chemotherapy drug showed great potential as tumor-targeted drug delivery carrier.
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