期刊
CARBOHYDRATE POLYMERS
卷 180, 期 -, 页码 104-111出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.10.031
关键词
Bone tissue engineering; Scaffold; Ethyl cellulose; Hydroxyapatite; Poly(lactic acid)
资金
- National Natural Science Foundation of China [51103120]
A major challenge in bone tissue engineering is the development of biomimetic scaffolds which should simultaneously meet mechanical strength and pore structure requirements. Herein, we combined technologies of high concentration solvent casting, particulate leaching, and room temperature compression molding to prepare a novel poly(lactic acid)/ethyl cellulose/hydroxyapatite (PLA/EC/HA) scaffold. The functional, structural and mechanical properties of the obtained porous scaffolds were characterized. The results indicated that the PLA/ EC/HA scaffolds at the 20 wt% HA loading level showed optimal mechanical properties and desired porous structure. Its porosity, contact angle, compressive yield strength and weight loss after 56 days were 84.28 +/- 7.04%, 45.13 +/- 2.40 degrees, 1.57 +/- 0.09 MPa and 4.77 +/- 0.32%, respectively, which could satisfy the physiological demands to guide bone regeneration. Thus, the developed scaffolds have potential to be used as a bone substitute material for bone tissue engineering application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据