期刊
CARBOHYDRATE POLYMERS
卷 182, 期 -, 页码 180-187出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.11.023
关键词
Chitosan; Chemical modification; Click chemistry; 1,2,3-Triazolium; Pyridinium; Antifungal activity
资金
- National Natural Science Foundation of China [41576156]
- National Key Research and Development Program-China [2016YFF0202304]
- Shandong Province Science and Technology Development Plan [2015GSF121045]
- Yantai Science and Technology Development Plan [2015ZH078]
- Public Science and Technology Research Funds Projects of Ocean [201505022-3]
In this paper, novel cationic chitosan derivative possessing 1,2,3-triazolium and pyridinium groups was synthesized conveniently via cuprous-catalyzed azide-alkyne cycloaddition (CuAAC) and methylation. FTIR, H-1 NMR, and elemental analysis examined the structural characteristics of the synthesized derivatives. The antifungal efficiencies of chitosan derivatives against three plant-threatening fungi were assayed by hypha measurement in vitro. The determination showed that chitosan derivative bearing 1,2,3-triazolium and pyridinium displayed tremendously enhanced antifungal activity as compared with chitosan and chitosan derivative bearing 1,2,3-triazole and pyridine. Notably, the inhibitory indices of it against Colletotrichum lagenarium attained 98% above at 1.0 mg/mL. The results showed that N-methylation of 1,2,3-triazole and pyridine could effectively enhance antifungal activity of the synthesized chitosan derivatives. Besides, the prepared chitosan derivatives showed non-toxic effect on cucumber seedlings. This synthetic strategy might provide an effective way and notion to prepare novel cationic chitosan antifungal biomaterials.
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