期刊
CARBOHYDRATE POLYMERS
卷 181, 期 -, 页码 394-403出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.10.048
关键词
Hyaluronan; Lignin; Hydrogel; Swelling behaviour; Mechanical properties; Biocompatibility of hydrogels
资金
- Operational Program Research and Development Fund (ERDF)
- national budget of the Czech Republic [CZ.1.05/2.1.00/03.0111]
- Ministry of Education, Youth and Sports of the Czech Republic - Program NPU I [LO1504]
- TBU in Zlin [IGA/FT/2013/015, IGA/FT/2014/018]
- Czech Science Foundation [17-05095S]
- project, Materials Research Centre -Sustainability and Development of the Ministery of Education, Youth and Sport of the Czech Republic [LO1211]
Effects of the addition of water soluble glycinated Kraft lignin (WS/KL) on the mechanical stability and biocompatibility of hyaluronan (NaHy) hydrogels were evaluated in this work. Water soluble lignin was obtained by the modification of Kraft lignin via a Mannich reaction. It was found that WS/KL is highly compatible with hyaluronan due to its improved water solubility, which favours its use in designing new advanced composite hydrogels. The effects of the concentration of WS/KL on morphological, swelling and creep/recovery behaviours of hyaluronan hydrogels were investigated. It was detected that the creep resistance and creep recovery of NaHy hydrogels was improved by the incorporation of up to 3% (w/w) of WS/KL. In contrast, the swelling capacity of hydrogels was decreased. The cytotoxicity tests proved that glycinated KL lignin limits the viability of cells only slightly, and the final hyaluronan/lignin hydrogels were non-toxic materials.
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