期刊
CARBOHYDRATE POLYMERS
卷 190, 期 -, 页码 271-280出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.02.086
关键词
Alginate; Click chemistry; Diels-Alder; Hydrogel; Drug delivery
资金
- Agence Nationale de la Recherche-France (ANR) [ANR-13-ECOT-0004 CHWWEPS]
- AUF (Agence Universitaire de la Francophonie), project BIOCOMPMAT
Environment-sensitive alginate-based hydrogels for drug delivery applications are receiving increasing attention. However, most work in this field involves traditional cross-linking strategies which led to hydrogels with poor long-term stability. Herein, a series of chemically cross-linked alginate hydrogels was synthesized via click chemistry using Diels-Alder reaction by reacting furan-modified alginate and bifunctional cross-linkers. Alginate was successfully functionalized with furfurylamine. Then, 3D architectures were synthesized with water-soluble bismaleimides. Different substitution degrees were achieved in order to study the effect of alginate modification and the cross-linking extent over the behaviour of the hydrogels. The ensuing hydrogels were analysed in terms of microstructure, swelling, structure modification and rheological behaviour. The materials response to external stimuli such as pH was also investigated, revealing a pulsatile behaviour in a large pH range (1-13) and a clear pH-dependent swelling. Finally, vanillin release studies were conducted to demonstrate the potential of these biobased materials for drug delivery applications.
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