期刊
CARBOHYDRATE POLYMERS
卷 180, 期 -, 页码 1-12出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.10.019
关键词
Chitosan derivative; Characterization; Antibacterial activity; Biocompatibility; Wound healing property
资金
- Applied Basic Research Program for Youngster of Qingdao [15-9-1-42-jch]
- National Natural Science Foundation of China (NSFC) [31400812]
- Shandong Province Natural Science Foundation [ZR2014CQ052]
- Science and Technology Development Funds of Qingdao Shinan [2014-14-003-SW, 2015-5-015-ZH]
This work aims to prepare 3,6-O-N-acetylethylenediamine modified chitosan (AEDMCS) and evaluate its potential use as an antimicrobial wound dressing material. UV, FTIR, and H-1 NMR results demonstrated N-acetylethylenediamine groups were successfully grafted to C3-OH and C6-OH on polysaccharide skeletons. TGA, XRD, and solubility tests indicated that as compared with chitosan, AEDMCS had diminished thermostability, decreased crystallinity, and greatly improved solubility. AEDMCS, with degrees of deacetylation and substitution being respectively 90.3% and 0.72, exhibited higher antibacterial activity than chitosan against six bacteria generally causing wound infections. Meanwhile, AEDMCS had permissible hemolysis and cytotoxicity and low BSA adsorption even at a AEDMCS concentration of 25 mg/mL. Acute toxicity tests showed AEDMCS was nontoxic. Moreover, the wound healing property was preliminarily evaluated, illustrating that AEDMCS enhanced wound healing rates as expected and had no significant differences as compared with chitosan. These results suggested AEDMCS might be a potential material used as antibacterial wound dressings.
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