期刊
CARBOHYDRATE POLYMERS
卷 180, 期 -, 页码 238-245出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.10.026
关键词
Dendrobium devonianum; Chain conformation; Saccharide mapping; Immunomodulatory activity
资金
- National Natural Science Foundation of China [81673389, 81603069]
- Science and Technology Development Fund of Macau [074/2016/A2, 040/2016/A]
- University of Macau [MYRG2015-00202, MYRG2015-00122]
The chain conformation, chemical characters and immunomodulatory activity of polysaccharide from Dendrobium devonianum (DDP) were investigated. Results showed that molecular weights, polydispersity index, radius of gyrations of DDP were 3.99 x 10(5) Da 1.27, 74.1 nm, respectively. By applying the polymer solution theory, the exponent (v) values of (1/2)(z) = kM(w)(v) was calculated as 0.38, which revealed that DDP existed as a globular shape in aqueous solution, and further confirmed by AFM analysis. Furthermore, the main monosaccharide compositions were Man and Glc with the ratio of 29.61:1.00. Indeed, the main glycosidic linkages were beta-1,4-Manp, and substituted with acetyl groups at O-2 and O-3 position. Notably, DDP could promote the immune functions of macrophages including NO release and phagocytosis. Thus, DDP could be explored as a natural immune-stimulating agent in the health and functional food area as well as pharmaceutical industries.
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