期刊
CARBOHYDRATE POLYMERS
卷 180, 期 -, 页码 365-375出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.10.030
关键词
Paclitaxel; Nanotherapy; Glioblastoma; Stem cells; Hemocompatible; Nanomedicine
资金
- Institute of Nano Science and Technology (INST Mohali, Punjab, India) intramural fund
- Science and Engineering Research Board (SERB) [YSS/2015/001706, ECR/2016/000633/LS]
- Council of Scientific and Industrial Research
- University Grant Commission
Recurrence of glioblastoma is one of the major concerns due to its heterogeneous nature and association of Glioma Initiating stem-like Cells (GICs). Nanoparticles mediated delivery of chemotherapeutic agent targeting both cancer and glioma stem cells could provide a solution to recurrent malignancies of the glioblastoma tumor. The approach described here provides enhanced chemotherapeutic potency utilizing 1,3 beta-Glucan as an outer shell to the chitosan nanoparticles (Cs-NPs) loaded with paclitaxel to prevent hemolysis with, the core-shell nano-structure (Cs-PTX-NP) enabling effective chemotherapy against malignant glioblastoma. The prepared nanoparticles (1,3 beta-Cs-PTX-NPs) with sustained release of the paclitaxel provide a targeted therapeutic approach that overcome systemic toxicities with the 1,3 beta-Glucan shell and improve drug bioavailability. Hemolysis investigation indicated that 1,3 beta-Cs-PTX-NP was significantly less hemolytic than paclitaxel enabling intravenous delivery. Also, 1,3 beta-Cs-PTX-NPs were considerably more cytotoxic (IC50) against glioma cancer LN18 cells and C6 stem-like cells compared with the PTX. In conclusion, this study found that 1,3 beta-Cs-PTX-NP addressed serious limitation with systemic delivery of paclitaxel by preventing hemolysis and providing chemotherapeutic delivery with significant anti-cancer efficacy against recurrent glioblastoma.
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