期刊
CARBOHYDRATE POLYMERS
卷 188, 期 -, 页码 27-36出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.01.093
关键词
Nanocellulose; Cellulose nanofibrils; Polydopamine; Hydrogel; Drug delivery; Wound healing
资金
- National Natural Science Foundation of China [31470609, 31700509, 21476091]
- National Key Research and Development Program of China [2017YFB0307900]
- Primary Research and Development Plan of Shandong Province [2016CYJS07A02]
In this study, we reported a pH/near-infrared (NIR)-responsive hydrogel for on-demand drug delivery and wound healing. Cellulose nanofibrils (TOCNFs) were produced by 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated oxidation method. Polydopamine (PDA) was introduced into TOCNFs network to fabricate a PDA/TOCNFs hydrogel through ion-crosslinking with calcium ion as a crosslinker. Then, tetracycline hydrochloride (TH) which loaded on PDA could be released from the prepared hydrogels in an on-demand fashion under NIR exposure or at lower pH conditions. In addition, the in vivo skin defect experiments illustrated that the resultant composite hydrogel had a synergistic effect on promoting wound healing. Therefore, owing to the unique pH/NIR responsiveness, long time period drug releasing property, antibacterial and mechanical properties, together with their biodegradability and biocompatibility, the prepared PDA/TOCNFs hydrogel is highly promising as a new drug delivery vehicle, offering simple and safe alternatives to the conventional systems based on the petroleum-based polymers.
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