期刊
FITOTERAPIA
卷 103, 期 -, 页码 1-8出版社
ELSEVIER
DOI: 10.1016/j.fitote.2015.03.004
关键词
Camptotheca acuminata; Camptothecin; Biosynthesis; Indole glucoside
资金
- program for New Century Excellent Talents in University [NCET-2013-1015]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1193]
Six new indole glucosides (1-6) and fifteen known alkaloids (7-21) were isolated from the fruit of Camptotheca acuminata. The planar structures of 1-6 were determined on the basis of spectroscopic data analysis and their absolute configurations were established by CD. The isolated indole glucosides showed a clear biosynthetic pathway of camptothecin (7), which started from tryptamine and secologanin and was proposed by synthetic chemists previously. Particularly, compound 1 supplemented the process of the transformation from pumiloside (20) or 3-epi-pumiloside (21) to camptothecin (7). In addition, camptothecin 10-O-beta-D-glucopyranoside (13) and norcamptothecin (17), synthesized in the early structural modification of 7, were first isolated from the natural resources. The new compounds 1-6 were screened for their in vitro cytotoxicity but they did not show any exciting result. (C) 2015 Elsevier B.V. All rights reserved.
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