期刊
CANCER SCIENCE
卷 109, 期 9, 页码 2677-2686出版社
WILEY
DOI: 10.1111/cas.13720
关键词
HMGB1; macrophage; myeloid-derived suppressor cells; resveratrol; tumor immunotherapy
类别
资金
- Key University Science Research Project of Jiangsu Province [16KJA320005]
- Social Development Foundation of Jiangsu Province [BE2016716]
- Six Talent Peaks Project in Jiangsu Province [2015-WSN-005]
- Maternal and Child Project in Jiangsu Province [F201511]
- Medical Development Foundation of Jiangsu University [JLY20160051]
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells which consist of 2 subsets: granulocytic MDSC (G-MDSC) and monocytic MDSC (M-MDSC). MDSC expand in tumor-bearing hosts and contribute to immunotherapeutic resistance by remarkably blocking effector T-cell activation via different mechanisms. Resveratrol (RSV) is a polyphenol and it has been widely used for its various health benefits. However, the underlying mechanism of its anti-tumor properties remains unclear. In this study, a transplantable mouse model was used to investigate the effects of RSV on MDSC. The results showed that RSV ameliorated tumor development by decreasing G-MDSC accumulation, impairing its suppressive ability on CD8(+)T cells and promoting M-MDSC differentiation into CD11c(+) and F4/80(+) cells. Our results indicated that RSV should be considered as a modular of MDSC suppressive function and that RSV is a novel booster for tumor immunotherapy.
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