期刊
CANCER SCIENCE
卷 109, 期 3, 页码 629-641出版社
WILEY
DOI: 10.1111/cas.13488
关键词
angiogenesis; exosomes; hepatocyte growth factor; siRNA; tumor therapy
类别
资金
- National Natural Science Foundation of China [81772629, 81602158, 81372394, 81602156, 81702437]
- Tianjin Health and Family Planning Commission Foundation of Science and Technology [15KG142]
- CSCO-Merck Serono Oncology Research Fund [Y-MX2015-092]
Exosomes derived from cells have been found to mediate signal transduction between cells and to act as efficient carriers to deliver drugs and small RNA. Hepatocyte growth factor (HGF) is known to promote the growth of both cancer cells and vascular cells, and the HGF-cMET pathway is a potential clinical target. Here, we characterized the inhibitory effect of HGF siRNA on tumor growth and angiogenesis in gastric cancer. In addition, we showed that HGF siRNA packed in exosomes can be transported into cancer cells, where it dramatically downregulates HGF expression. A cell co-culture model was used to show that exosomes loaded with HGF siRNA suppress proliferation and migration of both cancer cells and vascular cells. Moreover, exosomes were able to transfer HGF siRNA invivo, decreasing the growth rates of tumors and blood vessels. The results of our study demonstrate that exosomes have potential for use in targeted cancer therapy by delivering siRNA.
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