期刊
CANCER SCIENCE
卷 109, 期 8, 页码 2383-2390出版社
WILEY
DOI: 10.1111/cas.13654
关键词
adult T-cell leukemia; lymphoma; CTL; HTLV-1; programmed cell death protein 1; Tax
类别
资金
- Japan Agency for Medical Research and Development [16H04713, 17ck0106287h0001, 16cm0106301h0001, 15ck0106132h0002]
- Grants-in-Aid for Scientific Research [16H04713] Funding Source: KAKEN
Adult T-cell leukemia/lymphoma (ATL) is caused by Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1), and a higher HTLV-1 provirus load in PBMC is a risk factor for ATL development. Here, we document a significant inverse correlation between the function of HTLV-1 Tax-specific CTL (Tax-CTL), as assessed by exvivo cytokine production in response to cognate peptide, and the HTLV-1 provirus load in PBMC in both HTLV-1 asymptomatic carriers (AC) (Spearman rank correlation coefficient [Rs]=-0.494, P=.037, n=18) and ATL patients (Rs=-0.774, P=.001, n=15). There was also a significant correlation between the HTLV-1 provirus load and the percentage of PD-1-positive Tax-CTL in both HTLV-1 AC (Rs=0.574, P=.013) and ATL patients (Rs=0.676, P=.006). Furthermore, the percentage of PD-1-positive Tax-CTL was inversely correlated with their function in HTLV-1 AC (Rs=-0.542, P=.020), and ATL patients (Rs=-0.639, P=.010). These findings indicate that the function of Tax-CTL decreased as their programmed cell death protein 1 (PD-1) levels increased, parallel to the increased HTLV-1 provirus load in PBMC. We propose that functional Tax-CTL are crucial for determining the HTLV-1 provirus load in PBMC, not only in HTLV-1 AC, but also in ATL, and that PD-1 expression levels are reliable markers of Tax-CTL function. Thus, modulating the immunological equilibrium between Tax-CTL and HTLV-1-infected cells to achieve dominance of functional effectors could represent an ideal strategy for controlling HTLV-1-associated disease.
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