Prepartion and Characterization of Superparamagnetic Chitosan Coated Maghemite (γ-Fe2O3) for Gene Delivery

Maghemite (gamma - Fe2O3) nanoparticles have been synthesized successfully with controlled co-precipitation technique with ultrasonic. The crystal sizes determined by Drbye - Scherre equation with XRD data were found close to the particle sizes calculated from TEM images, and this indicates that the synthesized particles are nanocrystalline. FT-IR was used to characterize the chitosan coated nanoparticles, and it was found that chitosan coated maghemite nanoparticles were synthesized. The superparamagnetic behavior of nanoparticles was documented by the hysteresis loop measured with VSM spectrometer, and the magnetic saturation of about67 emu/gand residualfield of about 8.5 Oe were recorded for the nanoparticles. These synthesized core-shell nanoparticles have desired properties, which make them attractive for using in biomedical applications, such as gene delivery. (C) 2015 Published by Elsevier Ltd.