期刊
CANCER RESEARCH
卷 78, 期 11, 页码 2779-2786出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-17-3883
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资金
- Instituto Serrapilheira/Serra [1708-15285]
- Pro-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) [05/2016]
- FAPEMIG [Rede Mineira de Engenharia de Tecidos e Terapia Celular (REMETTEC)] [RED-00570-16]
- FAPEMIG [Rede De Pesquisa Em Doencas Infecciosas Humanas E Animais Do Estado De Minas Gerais] [RED 00313 16]
- NIH [1R01CA179072-01A1]
- American Cancer Society [124443-MRSG-13-121-01-CDD]
The premetastatic niche formed by primary tumor-derived molecules contributes to fixation of cancer metastasis. The design of efficient therapies is limited by the current lack of knowledge about the details of cellular and molecular mechanisms involved in the premetastatic niche formation. Recently, the role of pericytes in the premetastatic niche formation and lung metastatic tropism was explored by using state-of-the-art techniques, including in vivo lineage-tracing and mice with pericyte-specific KLF4 deletion. Strikingly, genetic inactivation of KLF4 in pericytes inhibits pulmonary pericyte expansion and decreases metastasis in the lung. Here, we summarize and evaluate recent advances in the understanding of pericyte contribution to premetastatic niche formation. (C) 2018 AACR.
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