期刊
CANCER LETTERS
卷 430, 期 -, 页码 193-200出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.05.030
关键词
Lipid nanoparticles; Osteosarcoma; Edelfosine; Lung metastases; Nanomedicine
类别
资金
- Asociacion Espanola Contra el Cancer (AECC) (Spain) [CI14142069BLAN]
- Fundacion Caja Navarra (Spain) [CAN 70565]
- Bone Cancer Research Trust (UK) [144681]
Osteosarcoma (OS) is the most frequent paediatric bone cancer, responsible for 9% of all cancer-related deaths in children. In this paper, a new strategy based on delivering edelfosine (ET) in lipid nanoparticles (LN) was explored in order to target the primary tumour and eliminate metastases. The in vitro and in vivo efficacy of the free drug, drug loaded into lipid nanoparticles (ET-LN) and doxorubicin (DOX) against osteosarcoma (OS) cells was analysed. ET and ET-LN decreased the growth of OS cells in vitro in a time- and dose-dependent manner. Interestingly, the uptake of ET and ET-LN was lower when OS cells were pre-treated with DOX. In vivo studies revealed that ET and ET-LN slowed down the primary tumour growth in two OS models. However, the combination of both drugs showed no additional anti-tumour effect. Importantly, ET-LN successfully prevented the metastatic spread of OS cells from the primary tumour to the lungs. On the whole, ET-LN are a promising candidate for OS chemotherapy.
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