The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways

Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells: they mediate the activation of caspase-1, leading to cellular pyroptosis. So far, a variety of studies on inflammasomes have emerged, and the best-studied is the NLRP3 inflammasome that is involved in many inflammatory responses. Furthermore, its relationship with metabolism is gaining increasing attention in this field. In this review, we discuss the importance of the NLRP3 inflammasome in metabolic disorders and its close association with metabolic pathways. (C) 2018 Elsevier B.V. All rights reserved.