期刊
CANCER LETTERS
卷 413, 期 -, 页码 46-58出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.10.044
关键词
Macrophages; Metabolism; Inflammatory diseases; Cancer
类别
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2017R1D1A1B04031161]
- Seoul National University (SNU)
- Seoul National University
Macrophages are now considered to be important players in various inflammatory diseases as well as tumor progression. Emerging evidence reveals that macrophage metabolic features are deeply associated with their immune functions. Understanding the interaction between cellular metabolism and immune signaling pathways in macrophages can help us to develop appropriate therapeutic approaches for inflammatory diseases. In this review, we briefly summarize key metabolic features of M1 and M2 macrophages as well as signaling interactions between major metabolic molecules with TLRs and NLRs. Current knowledges of cellular metabolism are focused on macrophages in various disease situations including sepsis, atherosclerosis, obesity, tuberculosis and cancer. Novel insights and present targets for regulating macrophage metabolism are also discussed. (c) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据