期刊
CANCER LETTERS
卷 420, 期 -, 页码 210-227出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.01.061
关键词
Natural compounds; Non-apoptotic cell death; Cancer
类别
资金
- National Natural Science Foundation of China [81672932, 81730108]
- Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars [LR18H160001]
- Zhejiang Provincial Natural Science Foundation of China [LY15H160028, LY13H130002]
- Zhejiang province medical science and technology project [2017RC007]
- Zhejiang province Ministry of Science and Technology [2015C03055]
- Zhejiang Association for Science and Technology [2017YCGC002]
- Zhejiang province science and technology project of TCM [2015ZB033]
- Hangzhou Ministry of Science and Technology [20162013A07, 20142013A63]
Traditional cancer therapy is mainly targeting on enhancing cell apoptosis, however, it is well established that many cancer cells are chemo-resistant and defective in apoptosis induction. Therefore, it may have important therapeutic implications to exploit some novel natural compounds based on non-apoptotic programmed cell death. Currently, accumulating evidence shows that the compounds from nature source can induce non-apoptotic programmed cell death in cancer cells, and therefore these natural compounds have gained a great promise for the future anticancer therapeutics. In this review, we will concentrate our efforts on the latest developments regarding major forms of non-apoptotic programmed cell death-autophagic cell death, necroptosis, ferroptosis, pyroptosis, glutamoptosis and exosome-associated cell death. Our increased understanding of the role of natural compounds in regulating non-apoptotic programmed cell death will hopefully provide prospective strategies for cancer therapy. (C) 2018 Elsevier B.V. All rights reserved.
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