期刊
CANCER LETTERS
卷 429, 期 -, 页码 29-40出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.05.004
关键词
PECAM-1; CD31; Hepatocellular carcinoma; Epithelial-mesenchymal transition; Integrin beta 1
类别
资金
- National Natural Science Foundation of China [81472224, 81672326]
- National Key Basic Research Program (973 project) [2015CB554005]
- Ministry of Science and Technology of China
- Leading Investigator Program of Shanghai [17XD1401100]
Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) is a well-known marker of endothelial cells and a key factor for adhesion and accumulation of platelets. CD31 plays roles in cell proliferation, apoptosis, migration, and cellular immunity. CD31 is also expressed on tumor cells, such as breast cancer cells and non Hodgkin's lymphomas, and contributes to tumor cell invasion. Here, our experiments show that CD31 promotes metastasis by inducing the epithelial mesenchymal transition in hepatocellular carcinoma by up-regulating integrin beta 1 via the FAK/Akt signaling pathway.
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