期刊
CANCER LETTERS
卷 414, 期 -, 页码 127-135出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.11.005
关键词
Adoptive cell transfer; Chimeric antigen receptor; Graft versus host disease; Hematopoietic stem cell transplant; Metabolism; Tumor infiltrating lymphocyte
类别
资金
- National Institute of Health - NHBLI [1K08-HL123631]
- Children's Hospital of Pittsburgh Research Advisory Committee
- University of Pittsburgh Physicians Academic Foundation
- Hyundai Motor Company (Hope on Wheels Scholar grant)
- American Society of Hematology (Scholar award)
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K08HL123631] Funding Source: NIH RePORTER
The immunology community has made significant strides in recent years in using the immune system to target and eliminate cancer. Therapies such as hematopoietic stem cell transplantation (HSCT) are the standard of care treatment for several malignancies, while therapies incorporating chimeric antigen receptor (CAR) T cells or checkpoint molecule blockade have been revolutionary. However, these approaches are not optimal for all cancers and in some cases, have failed outright. The greatest obstacle to making these therapies more effective may be rooted in one of the most basic concepts of cell biology, metabolism. Research over the last decade has revealed that T cell proliferation and differentiation is intimately linked to robust changes in metabolic activity, delineation of which may provide ways to manipulate the immuno-oncologic responses to our advantage. Here, we provide a basic overview of T cell metabolism, discuss what is known about metabolic regulation of T cells during allogeneic HSCT, point to evidence on the importance of T cell metabolism during CAR T cell and solid tumor therapies, and speculate about the role for compounds that might have dual-action on both immune cells and tumor cells simultaneously. (C) 2017 Elsevier B.V. All rights reserved.
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