期刊
CANCER JOURNAL
卷 24, 期 2, 页码 93-103出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0000000000000311
关键词
Circulating tumor cells; exosomes; extracellular vesicles; gene expression profiling; mutation detection; next-generation sequencing; polymerase chain reaction; precision medicine; tumor cell-free DNA
类别
资金
- National Institutes of Health [NIBIB P41-EB020594, IMAT R21-CA173279]
In the context of oncology, liquid biopsies consist of harvesting cancer biomarkers, such as circulating tumor cells, tumor-derived cell-free DNA, and extracellular vesicles, from bodily fluids. These biomarkers provide a source of clinically actionable molecular information that can enable precision medicine. Herein, we review technologies for the molecular profiling of liquid biopsy markers with special emphasis on the analysis of low abundant markers from mixed populations.
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