期刊
CANCER CELL
卷 33, 期 5, 页码 829-+出版社
CELL PRESS
DOI: 10.1016/j.ccell.2018.04.004
关键词
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资金
- F. Hoffmann-La Roche Ltd [BO25041, NCT01390948]
- NHS funding
- Associazione per la Ricerca sui Tumori Cerebrali del Bambino
The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years. We carried out comprehensive molecular analysis integrated with pathology, radiology, and immune profiling. In post-hoc subgroup analysis, hypermutator tumors (mismatch repair deficiency and somatic POLE/POLD1 mutations) and those biologically resembling pleomorphic xanthoastrocytoma ([PXA]-like, driven by BRAF_V600E or NF1 mutation) had significantly more CD8(+) tumor-infiltrating lymphocytes, and longer survival with the addition of BEV. Histone H3 subgroups (hemispheric G34R/V and midline K27M) had a worse outcome and were immune cold. Future clinical trials will need to take into account the diversity represented by the term HGG'' in the pediatric population.
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