期刊
CANCER CAUSES & CONTROL
卷 29, 期 3, 页码 389-397出版社
SPRINGER
DOI: 10.1007/s10552-018-1003-6
关键词
Chemoprevention; Colorectal cancer; Dietary supplements; Epidemiology; Glucosamine
资金
- Centers for Disease Control and Prevention's National Program of Cancer Registries
- National Cancer Institute's Surveillance Epidemiology and End Results program
- National Cancer Institute of the National Institutes of Health [P30 CA008748]
Use of glucosamine supplements has been associated with reduced risk of colorectal cancer (CRC) in previous studies; however, information on this association remains limited. We examined the association between glucosamine use and CRC risk among 113,067 men and women in the Cancer Prevention Study II Nutrition Cohort. Glucosamine use was first reported in 2001 and updated every 2 years thereafter. Participants were followed from 2001 through June of 2011, during which time 1440 cases of CRC occurred. As has been observed in prior studies, current use of glucosamine, modeled using a time-varying exposure, was associated with lower risk of CRC (HR 0.83; 95% CI 0.71-0.97) compared to never use. However, for reasons that are unclear, this reduction in risk was observed for shorter-duration use (HR 0.68; 95% CI 0.52-0.87 for current users with ae 2 years use) rather than longer-duration use (HR 0.90; 95% CI 0.72-1.13 for current users with 3 to < 6 years of use; HR 0.99; 95% CI 0.76-1.29 for current users with ae 6 years of use). Further research is needed to better understand the association between glucosamine use and risk of CRC, and how this association may vary by duration of use.
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