期刊
EUROSENSORS 2015
卷 120, 期 -, 页码 952-955出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.proeng.2015.08.816
关键词
Microelectrode array; Intracortical neural probe; Flexible substrate; Biodegradable materials; Polyethylene glycol; Molding; Silicon
A hybridly assembled, neural probe based on silicon (Si) with reduced dimensions and improved mechanical flexibility is proposed as a chronic neural interface. In contrast to previous approaches, the microelectrode array at the probe tip will be completely implanted into cortical tissue and tethered only by a slender and highly flexible, 11-mu m-thick polyimide cable. The Si-based electrode arrays carry 16 or 32 channels and feature cross-sections as small as 50 x 120 mu m(2) across their entire length. Implantation of the flexible probes is facilitated by a temporary increase in probe stiffness using a bio-dissolvable polymer coating. The centrifuge-based molding of polyethylene glycol creates sharp insertion vehicles with a thickness of only 75 mu m. Probe implantation up to 9 mm into agar-based brain models demonstrates the insertion capability of the novel mechanically adaptive neural probes. (C) 2015 The Authors. Published by Elsevier Ltd.
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