期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 164, 期 6, 页码 775-779出版社
SPRINGER
DOI: 10.1007/s10517-018-4078-x
关键词
endotheliocytes; induced pluripotent stem cells; sepsis; sphingosine-1-phosphate
资金
- KAKENHI grant from the Japan Society for the Promotion of Science [25861727]
- Grants-in-Aid for Scientific Research [25861727] Funding Source: KAKEN
The possibility of sphingosine-1-phosphate production by induced pluripotent stem cells is examined to assess their potential in treatment of sepsis. The hematopoietic embryoid bodies were derived from the culture of 6-day-old differentiated induced pluripotent stem cells. These embryoid bodies secreted sphingosine-1-phosphate, an important bioactive lipid that regulates integrity of the pulmonary endothelial barrier, prevents elevation of its permeability, and impedes the formation of stress fibers in human endotheliocytes derived from umbilical vein. The data attest to potentiality of induced pluripotent stem cells in treatment of sepsis.
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