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Fei Gao et al.
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Vincent Chung et al.
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Fei Gao et al.
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Qi Wang et al.
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Chia-Wei Li et al.
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Fei Gao et al.
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Phase 2 study of MK-2206, an allosteric inhibitor of AKT, as second-line therapy for advanced gastric and gastroesophageal junction cancer: A SWOG cooperative group trial (S1005)
Ramesh K. Ramanathan et al.
CANCER (2015)
New insights in the control of vascular permeability: vascular endothelial-cadherin and other players
Marianna Trani et al.
CURRENT OPINION IN HEMATOLOGY (2015)
Genetic deletion and pharmacological inhibition of Akt1 isoform attenuates bladder cancer cell proliferation, motility and invasion
Harika Sabbineni et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2015)
Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer
Khanh Do et al.
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Glycogen synthase kinase 3 in Wnt signaling pathway and cancer
Nydia Tejeda-Munoz et al.
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Broad targeting of angiogenesis for cancer prevention and therapy
Zongwei Wang et al.
SEMINARS IN CANCER BIOLOGY (2015)
Preclinical and Early Clinical Evaluation of the Oral AKT Inhibitor, MK-2206, for the Treatment of Acute Myelogenous Leukemia
Marina Y. Konopleva et al.
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Clinically Relevant Doses of Candesartan Inhibit Growth of Prostate Tumor Xenografts In Vivo through Modulation of Tumor Angiogenesis
Ahmed Alhusban et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)
P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor β Expression and Enhanced Matrix Metalloproteinase 9 Secretion
Anna Goc et al.
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Akt1 Mediates α-Smooth Muscle Actin Expression and Myofibroblast Differentiation via Myocardin and Serum Response Factor
Maha Abdalla et al.
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Suppression of Interactions Between Prostate Tumor Cell-Surface Integrin and Endothelial ICAM-1 by Simvastatin Inhibits Micrometastasis
Belal Al-Husein et al.
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The beta-Catenin Destruction Complex
Jennifer L. Stamos et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Tumor Endothelial Cells
Andrew C. Dudley
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Anticancer Efficacy of Simvastatin on Prostate Cancer Cells and Tumor Xenografts Is Associated with Inhibition of Akt and Reduced Prostate-Specific Antigen Expression
Samith T. Kochuparambil et al.
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Akt-Mediated Transactivation of the S1P1 Receptor in Caveolin-Enriched Microdomains Regulates Endothelial Barrier Enhancement by Oxidized Phospholipids
Patrick A. Singleton et al.
CIRCULATION RESEARCH (2009)
The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt
P. R. Somanath et al.
ONCOGENE (2009)
MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells
Dimitrios Iliopoulos et al.
SCIENCE SIGNALING (2009)
Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering src through mDia
Julie Gavard et al.
DEVELOPMENTAL CELL (2008)
The role of adherens junctions and VE-cadherin in the control of vascular permeability
Elisabetta Dejana et al.
JOURNAL OF CELL SCIENCE (2008)
VE-cadherin and claudin-5: it takes two to tango
Julie Gavard et al.
NATURE CELL BIOLOGY (2008)
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
Andrea Taddei et al.
NATURE CELL BIOLOGY (2008)
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
Christopher A. Jones et al.
NATURE MEDICINE (2008)
Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt
Y Mukai et al.
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Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors - A novel pathway relevant to the pathophysiology of endothelium
C De Palma et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
JH Chen et al.
NATURE MEDICINE (2005)
Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
C Daly et al.
GENES & DEVELOPMENT (2004)