期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 49, 期 2, 页码 483-491出版社
IOS PRESS
DOI: 10.3233/JAD-150556
关键词
Alzheimer's disease; amnestic mild cognitive impairment; body mass index; dementia; progression
资金
- Basic Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2013R1A1A2065365]
- Korean Healthcare Technology RAMP
- D Project Ministry for Health AMP
- Welfare Affairs [HI10C2020, HIC120713]
- Korea Ministry of Environment (MOE) [2014001360002]
- KOSEF NRL program grant (MEST) [2011-0028333]
- Samsung Medical Center [CRL-108011CRS110-14-1]
- Converging Research Center Program through the Ministry of Science, ICT and Future Planning, Korea [2013K000338]
- Korea Health Technology RAMP
- D Project through the Korea Health Industry Development Institute(KHIDI) - Ministry of Health AMP
- Welfare, Republic of Korea [HI14C2768]
Background and Objective: We investigated the influence of body mass index (BMI) status at baseline and changes in BMI over a follow-up period on the development of dementia in amnestic mild cognitive impairment (aMCI) patients. Methods: The longitudinal data of 747 aMCI patients were used to investigate the relationships among baseline BMI status, subsequent changes in BMI (median follow-up duration: 1.6 years, interquartile range: 1.0-2.3 years), and risk of progression to probable Alzheimer's disease dementia (pADD). The aMCI patients were classified into underweight, normal weight, overweight, and obese subgroups, and further categorized into increased BMI, stable BMI, and decreased BMI subgroups during follow-up using a 4% mean annual change in BMI cut-off value. Results: Compared to the normal weight group, the underweight group had a higher risk of pADD (hazard ratio [HR]: 1.89, 95% confidence interval [CI]: 1.07-3.37) while the obese group had a lower risk (HR: 0.70, 95% CI: 0.49-0.999). After controlling for baseline BMI status, the decreased BMI (HR: 2.29, 95% CI: 1.41-3.72) and increased BMI (HR: 3.96, 95% CI: 2.62-6.00) groups were at increased risk of progression to pADD. Conclusions: Our findings suggested that underweight at baseline was associated with a higher risk of progression to pADD, while obesity at baseline predicted a lower risk. Furthermore, significant changes in BMI during the follow-up period reflected an increased risk of progression to pADD, regardless of BMI status at baseline.
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