期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 170, 期 2, 页码 213-219出版社
SPRINGER
DOI: 10.1007/s10549-018-4753-7
关键词
p53; Breast cancer; Triple-negative; Biomarker; Therapeutic target; APR-246
类别
资金
- Science Foundation Ireland
- Strategic Research Cluster Award to Molecular Therapeutics for Cancer Ireland [08/SRC/B1410]
- Clinical Cancer Research Trust
- Irish Cancer Society Collaborative Cancer Research Centre BREAST-PREDICT programme [CCRC13GAL]
- Health Research Board Clinician Scientist Award [CSA/2007/11]
The aim of this article is to discuss mutant p53 as a possible therapeutic target and biomarker for breast cancer. TP53 (p53) is the most frequently mutated gene in invasive breast cancer. Although mutated in 30-35% of all cases, p53 is mutated in approximately 80% of triple-negative (TN) tumors (i.e., tumors negative for ER, PR, and HER2). Because of this high prevalence, mutated p53 is both a potential biomarker and therapeutic target for patients with breast cancer, especially for those with the TN subtype. Although several retrospective studies have investigated a potential prognostic and therapy predictive role for mutant p53 in breast cancer, the results to date are mixed. Thus, at present, mutant p53 cannot be recommended as a prognostic or therapy predictive biomarker in breast cancer. In contrast to the multiple reports on a potential biomarker role, few studies had until recently, investigated mutant p53 as a potential target for breast cancer treatment. In the last decade, however, several compounds have become available which can reactivate mutant p53 protein and convert it to a conformation with wild-type properties. Some of these compounds, especially PRIMA-1, APR-246 PK11007, and COTI-2, have been found to exhibit anticancer activity in preclinical models of breast cancer. Since p53 is mutated in the vast majority of TN breast cancers, compounds such as APR-246, PK11007, and COTI-2 are potential treatments for patients with this subform of the disease. Further research is necessary to identify a potential biomarker role for mutant p53 in breast cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据