期刊
BRAIN STRUCTURE & FUNCTION
卷 223, 期 5, 页码 2073-2095出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-018-1611-7
关键词
Adulthood; Cortical plasticity; Multimodal; Somatostatin interneurons; Optogenetic stimulation; Dark exposure
资金
- Agency for Innovation through Science and Technology, strategic basic research (IWT-SBO) [110068]
- Fund for Scientific Research (FWO)-Flanders [G065913N, G0D7614N]
- European project FP7 [ICT-2011-C-284801, HEALTH-F2-2011-278850]
- IWT Flanders [121240]
Unilateral vision loss through monocular enucleation (ME) results in partial reallocation of visual cortical territory to another sense in adult mice. The functional recovery of the visual cortex occurs through a combination of spared-eye potentiation and cross-modal reactivation driven by whisker-related, somatosensory inputs. Brain region-specific intracortical inhibition was recently recognized as a crucial regulator of the cross-modal component, yet the contribution of specific inhibitory neuron subpopulations remains poorly understood. Somatostatin (SST)-interneurons are ideally located within the cortical circuit to modulate sensory integration. Here we demonstrate that optogenetic stimulation of visual cortex SST-interneurons prior to eye removal decreases ME-induced cross-modal recovery at the stimulation site. Our results suggest that SST-interneurons act as local hubs, which are able to control the influx and extent of cortical cross-modal inputs into the deprived cortex. These insights critically expand our understanding of SST-interneuron-specific regulation of cortical plasticity induced by sensory loss.
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