期刊
BRAIN STIMULATION
卷 11, 期 2, 页码 322-326出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2017.10.014
关键词
Transcranial magnetic stimulation; Motor evoked potential; Short-interval intracortical facilitation; Indirect wave; Biomedical engineering; Motor cortex
资金
- State Research Funding, Kuopio, Finland [5041726, 5041730, 5041749]
- Cancer Society of Finland, Helsinki Finland
- Paivikki and Sakari Sohlberg Foundation, Helsinki, Finland
Background: Transcranial magnetic stimulation (TMS) induced I-wave behavior can be demonstrated at neuronal population level using paired-pulses and by observing short-interval cortical facilitation (SICF). Advancements in stimulator technology have made it possible to apply biphasic paired-pulses to induce SICF. Objective: Our aim was to characterize the SICF I-wave interaction by biphasic paired-pulses with the ultimate objective to enhance TMS effects via SICF in various TMS-applications. Methods: We used biphasic paired-pulses in 15 volunteers to characterize corticospinal SICF using various 1.2-8.0ms inter-stimulus intervals, and measuring SICF input-output response. Results: SICF interaction with the first I-wave (I1) was observed in the output responses (motor evoked potentials; MEPs) in all subjects. Most subjects (>= 80%) also exhibited later SICF I-wave interaction. SICF at I1 was present at all applied intensities below 140% of resting motor threshold. At I2, we observed SICF only with intensities just above motor threshold. Conclusions: Biphasic paired-pulses can reliably induce SICF shown by the facilitatory I-wave interaction, and could therefore be applied with repetitive bursts to enhance responsiveness to TMS. (c) 2017 Elsevier Inc. All rights reserved.
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