期刊
BRAIN RESEARCH BULLETIN
卷 136, 期 -, 页码 109-117出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2017.03.011
关键词
Bidirectional purinergic signaling; Enteric glial cells; Enteric neurons; Enteric nervous system; Gliotransmission
资金
- Civitan International Emerging Scholar Award at University of Alabama at Birmingham
- National Institutes of Health (The Eunice Kennedy Shriver National Institute of Child Health and Human Development) [HD078678]
- Research Agency of Slovenia [P3 0310, J3 6790, J3 7605]
The enteric nervous system, often referred to as the second brain, is the largest assembly of neurons and glia outside the central nervous system. The enteric nervous system resides within the wall of the digestive tract and regulates local gut reflexes involved in gastrointestinal motility and fluid transport; these functions can be accomplished in the absence of the extrinsic innervation from the central nervous system. It is neurons and their circuitry within the enteric nervous system that govern the gut reflexes. However, it is becoming clear that enteric glial cells are also actively involved in this process through the bidirectional signaling with neurons and other cells in the gut wall. We synthesize the recently discovered modulatory roles of enteric gliotransmission in gut motility and provide our perspective for future lines of research.
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