期刊
BRAIN RESEARCH
卷 1678, 期 -, 页码 85-93出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2017.10.001
关键词
Alzheimer's disease; Diospyros kaki; Flavonoids; Cognitive dysfunction; Amyloid metabolism; Inflammation
资金
- Science and Technology Development Planning Project of Shandong Province [2014GSF118056]
- National Natural Science Foundation of China [81371225]
Amyloid-beta peptide (A beta) initiates a cascade of pathological events, including activation of microglial cells, oxidative stress, and inflammation, leading to neuronal death and the typical pathological changes in Alzheimer's disease (AD). Flavonoids have been reported to exert neuroprotective activities, not only through their generally accepted antioxidant effects, but also through their ability to protect against neurotoxin-induced injury. Flavonoids reduce All production, inhibit neuroinflammation, increase cerebrovascular function, and improve cognitive performance. Here, we analyzed the effects of a flavonoid-rich ethanol extract from the leaves of Diospyros kaki (FLDK) in APP/PS1 transgenic mice. We found that oral treatment with FLDK reversed learning and memory impairment, reduced A beta burden and expression of beta-site amyloid precursor protein cleavage enzyme 1 (BACE1), and decreased microglial activation in senile plaques. FLDK restored antioxidant enzyme activities, as well as reduced the lipid peroxidation product, malondialdehyde, and inflammatory mediators. These results demonstrate that FLDK alleviates cognitive decline and reduces A beta burden, microglial activation, oxidative stress, and inflammation responses. Thus, FLDK treatment may be a potential therapeutic strategy for preventing and treating AD, at least in part via its anti-oxidant and anti-inflammatory biological activities and its effect on the A beta producing enzyme BACE1. (C) 2017 Elsevier B.V. All rights reserved.
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