4.5 Article

Common and distinct changes of default mode and salience network in schizophrenia and major depression

期刊

BRAIN IMAGING AND BEHAVIOR
卷 12, 期 6, 页码 1708-1719

出版社

SPRINGER
DOI: 10.1007/s11682-018-9838-8

关键词

Functional MRI; Diffusion tensor imaging; Schizophrenia; Depression; Default mode network; Salience network

资金

  1. National Natural Science Foundation of China [61403062, 61433014]
  2. China Postdoctoral Science Foundation [2015M580786, 2014M552344, 2015T80973]
  3. Science-Technology Foundation for Young Scientist of SiChuan Province [2016JQ0007]
  4. German Federal Ministry of Education and Research [BMBF 01EV0710, BMBF 01ER0803]

向作者/读者索取更多资源

Brain imaging reveals schizophrenia as a disorder of macroscopic brain networks. In particular, default mode and salience network (DMN, SN) show highly consistent alterations in both interacting brain activity and underlying brain structure. However, the same networks are also altered in major depression. This overlap in network alterations induces the question whether DMN and SN changes are different across both disorders, potentially indicating distinct underlying pathophysiological mechanisms. To address this question, we acquired T1-weighted, diffusion-weighted, and resting-state functional MRI in patients with schizophrenia, patients with major depression, and healthy controls. We measured regional gray matter volume, inter-regional structural and intrinsic functional connectivity of DMN and SN, and compared these measures across groups by generalized Wilcoxon rank tests, while controlling for symptoms and medication. When comparing patients with controls, we found in each patient group SN volume loss, impaired DMN structural connectivity, and aberrant DMN and SN functional connectivity. When comparing patient groups, SN gray matter volume loss and DMN structural connectivity reduction did not differ between groups, but in schizophrenic patients, functional hyperconnectivity between DMN and SN was less in comparison to depressed patients. Results provide evidence for distinct functional hyperconnectivity between DMN and SN in schizophrenia and major depression, while structural changes in DMN and SN were similar. Distinct hyperconnectivity suggests different pathophysiological mechanism underlying aberrant DMN-SN interactions in schizophrenia and depression.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据