期刊
GENOME BIOLOGY
卷 16, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13059-015-0833-8
关键词
Assortative mating; Genome structure; Missing heritability
资金
- Medical Research Council [MR/K014781/1]
- BBSRC
- Medical Research Council Human Genetics Unit
- BBSRC [BBS/E/D/20211553] Funding Source: UKRI
- MRC [MR/N003179/1, MR/K014781/1, MC_PC_U127592696] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20211553] Funding Source: researchfish
- Medical Research Council [MC_qA137853, MR/N003179/1, MR/K014781/1, MC_PC_U127592696] Funding Source: researchfish
Background: Numerous studies have reported positive correlations among couples for height. This suggests that humans find individuals of similar height attractive. However, the answer to whether the choice of a mate with a similar phenotype is genetically or environmentally determined has been elusive. Results: Here we provide an estimate of the genetic contribution to height choice in mates in 13,068 genotyped couples. Using a mixed linear model we show that 4.1 % of the variation in the mate height choice is determined by a person's own genotype, as expected in a model where one's height determines the choice of mate height. Furthermore, the genotype of an individual predicts their partners' height in an independent dataset of 15,437 individuals with 13 % accuracy, which is 64 % of the theoretical maximum achievable with a heritability of 0.041. Theoretical predictions suggest that approximately 5 % of the heritability of height is due to the positive covariance between allelic effects at different loci, which is caused by assortative mating. Hence, the coupling of alleles with similar effects could substantially contribute to the missing heritability of height. Conclusions: These estimates provide new insight into the mechanisms that govern mate choice in humans and warrant the search for the genetic causes of choice of mate height. They have important methodological implications and contribute to the missing heritability debate.
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