期刊
BRAIN
卷 141, 期 -, 页码 357-364出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awx337
关键词
neuropathic pain; brainstem; functional connectivity; diabetic neuropathy; facilitation
资金
- National Institute for Health Research Oxford Biomedical Research Centre
- Medical Research Council of Great Britain and Northern Ireland
- Wellcome Trust (London, UK)
- Innovative Medicines Initiative Joint Undertaking (Brussels, Belgium) [115007]
- European Union
- EFPIA
- European Commission [633491]
- Wellcome [102645]
The descending pain modulatory system represents one of the oldest and most fundamentally important neurophysiological mechanisms relevant to pain. Extensive work in animals and humans has shown how a functional imbalance between the facilitatory and inhibitory components is linked to exacerbation and maintenance of persistent pain states. Forward translation of these findings into clinical populations is needed to verify the relevance of this imbalance. Diabetic polyneuropathy is one of the most common causes of chronic neuropathic pain; however, the reason why similar to 25-30% of patients with diabetes develop pain is not known. The current study used a multimodal clinical neuroimaging approach to interrogate whether the sensory phenotype of painful diabetic polyneuropathy involves altered function of the ventrolateral periaqueductal grey-a key node of the descending pain modulatory system. We found that ventrolateral periaqueductal grey functional connectivity is altered in patients suffering from painful diabetic polyneuropathy; the magnitude of which is correlated to their spontaneous and allodynic pain as well as the magnitude of the cortical response elicited by an experimental tonic heat paradigm. We posit that ventrolateral periaqueductal grey-mediated descending pain modulatory system dysfunction may reflect a brain-based pain facilitation mechanism contributing to painful diabetic polyneuropathy.
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