期刊
BMC PEDIATRICS
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12887-018-1200-1
关键词
Newborn screening; Newborn sequencing; Whole exome sequencing; Methods; Randomized trial; Ethical; legal; social implications
类别
资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [U19 HD077671]
- National Human Genome Research Institute of The National Institutes of Health
Background: The greatest opportunity for lifelong impact of genomic sequencing is during the newborn period. The BabySeq Project is a randomized trial that explores the medical, behavioral, and economic impacts of integrating genomic sequencing into the care of healthy and sick newborns. Methods: Families of newborns are enrolled from Boston Children's Hospital and Brigham and Women's Hospital nurseries, and half are randomized to receive genomic sequencing and a report that includes monogenic disease variants, recessive carrier variants for childhood onset or actionable disorders, and pharmacogenomic variants. All families participate in a disclosure session, which includes the return of results for those in the sequencing arm. Outcomes are collected through review of medical records and surveys of parents and health care providers and include the rationale for choice of genes and variants to report; what genomic data adds to the medical management of sick and healthy babies; and the medical, behavioral, and economic impacts of integrating genomic sequencing into the care of healthy and sick newborns. Discussion: The BabySeq Project will provide empirical data about the risks, benefits and costs of newborn genomic sequencing and will inform policy decisions related to universal genomic screening of newborns.
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