期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms17020151
关键词
MPTP; neuroinflammation; microglia; Parkinson's disease; neurotrophic factors; neuroprotection
资金
- Excellence Initiative of the German Research Foundation (GSC-4 Spemann Graduate School)
- Intramural funding of the Medical Faculty of the University of Freiburg (Forschungskommission)
- Egyptian Ministry of Higher Education
- Deutsche Forschungsgemeinschaft [SP 1555/2-1]
Parkinson's disease (PD) is a neurodegenerative disease characterised by histopathological and biochemical manifestations such as loss of midbrain dopaminergic (DA) neurons and decrease in dopamine levels accompanied by a concomitant neuroinflammatory response in the affected brain regions. Over the past decades, the use of toxin-based animal models has been crucial to elucidate disease pathophysiology, and to develop therapeutic approaches aimed to alleviate its motor symptoms. Analyses of transgenic mice deficient for cytokines, chemokine as well as neurotrophic factors and their respective receptors in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD have broadened the current knowledge of neuroinflammation and neurotrophic support. Here, we provide a comprehensive review that summarises the contribution of microglia-mediated neuroinflammation in MPTP-induced neurodegeneration. Moreover, we highlight the contribution of neurotrophic factors as endogenous and/or exogenous molecules to slow the progression of midbrain dopaminergic (mDA) neurons and further discuss the potential of combined therapeutic approaches employing neuroinflammation modifying agents and neurotrophic factors.
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