期刊
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
卷 38, 期 2, 页码 108-117出版社
ELSEVIER INC
DOI: 10.1016/j.jogc.2015.12.014
关键词
Gestational weight gain; excessive; timing; newborn anthropometry
资金
- Fonds de la Recherche du Quebec - Sante (FRQ-S) operating grant
- Diabete Quebec
- Canadian Diabetes Association (CDA)
- Maud Menten Award from the Institute of Genetics-Canadian Institute of Health Research
- CDA
- FRSQ
Objective: Excessive gestational weight gain (GWG) is associated with increased birth weight and neonatal adiposity. However, timing of excessive GWG may have a differential impact on birth outcomes. The objective of this study was to compare the effect of early and mid/late excessive GWG on newborn anthropometry in the context of the Canadian clinical recommendations that are specific for first trimester and for second/third trimesters based onmaternal pre-pregnancy BMI. Methods: We included 607 glucose-tolerant women in our main analyses, after excluding women who had less than the recommended total GWG. Maternal body weight was measured in early pregnancy, mid-pregnancy, and late pregnancy. Maternal and fetal clinical outcomes were collected, including newborn anthropometry. Women were divided into four groups according to the Canadian guidelines for GWG in the first and in the second/third trimesters: (1) overall non-excessive (reference group); (2) early excessive GWG; (3) mid/late excessive GWG; and (4) overall excessive GWG. Differences in newborn anthropometry were tested across GWG categories. Results: Women had a mean (+/- SD) pre-pregnancy BMI of 24.7 +/- 5.2 kg/m(2) and total GWG of 15.3 +/- 4.4 kg. Women with mid/late excessive GWG gave birth to heavier babies (gestational age-adjusted birth weight z-score 0.33 +/- 0.91) compared with women in the reference group (0.00 +/- 0.77, P = 0.007), whereas women with early excessive GWG gave birth to babies of similar weight (gestational age-adjusted z-score 0.01 +/- 0.86) to the reference group (0.00 +/- 0.77, P = 0.84). When we stratified our analyses and investigated women who gained within the recommendations for total GWG, mid/late excessive GWG specifically was associated with greater newborn size, similar to our main analyses. Conclusion: Excessive GWG in mid/late pregnancy in women who did not gain weight excessively in early pregnancy is associated with increased birth size, even in those who gained within the Canadian recommendations for total GWG. Copyright (C) 2016 The Society of Obstetricians and Gynaecologists of Canada/La Societe des obstetriciens et gynecologues du Canada
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