期刊
BMC CANCER
卷 18, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s12885-018-4353-2
关键词
Breast cancer; Chemotherapy; Fasting; Pilot study; Quality of life; Ovarian cancer
类别
资金
- Gunter und Regine Kelm Stiftung, Zurich, Switzerland
Background: This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer. Methods: In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 planned chemotherapy cycles were included. Thirty-four patients were randomized to STF in the first half of chemotherapies followed by normocaloric diet (group A; n = 18) or vice versa (group B; n = 16). Fasting started 36 h before and ended 24 h after chemotherapy (60 h-fasting period). QOL was assessed by the FACIT-measurement system. Results: The chemotherapy-induced reduction of QOL was less than the Minimally Important Difference (MID; FACT-G = 5) with STF but greater than the MID for non-fasted periods. The mean chemotherapy-induced deterioration of total FACIT-F was 10.4 +/- 5.3 for fasted and 27.0 +/- 6.3 for non-fasted cycles in group A and 14.1 +/- 5.6 for non-fasted and 11.0 +/- 5.6 for fasted cycles in group B. There were no serious adverse effects. Conclusion: STF during chemotherapy is well tolerated and appears to improve QOL and fatigue during chemotherapy. Larger studies should prove the effect of STF as an adjunct to chemotherapy.
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