4.7 Article

Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury

期刊

BLOOD
卷 131, 期 18, 页码 2001-2006

出版社

AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2017-11-784108

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资金

  1. National Institutes of Health, National Institute of Neurological Disorders and Stroke [NS087296]
  2. National Heart, Lung, and Blood Institute [HL119391]
  3. Natural Science Foundation of China [81330029]
  4. [81271361]
  5. [81271359]

向作者/读者索取更多资源

Traumatic brain injury (TBI)-induced coagulopathy is a common and well-recognized risk for poor clinical outcomes, but its pathogenesis remains poorly understood, and treatment options are limited and ineffective. We discuss the recent progress and knowledge gaps in understanding this lethal complication of TBI. We focus on (1) the disruption of the brain-blood barrier to disseminate brain injury systemically by releasing brain-derived molecules into the circulation and (2) TBI-induced hypercoagulable and hyperfibrinolytic states that result in persistent and delayed intracranial hemorrhage and systemic bleeding.

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