Synthesis, characterization and catalytic activity of modified fluorapatite towards the multicomponent one-pot Biginelli condensation

Aliovalent ion substituted fluorapatite of formula Bi0.5Na0.5Ca4(PO4)(3)F was synthesized by co-precipitation method and characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy and energy dispersive X-ray spectroscopy. The catalytic activity of the synthesized compound was tested on one pot multicomponent reaction (Biginelli reaction) for the synthesis of 3,4-dihydropyrimidin-2(1H)-one and its derivatives. The compounds were confirmed by spectroscopic techniques and melting point. An enhanced yield was observed with this catalyst for the condensation of ethyl acetoacetate, urea and benzaldehyde compared to unsubstituted fluorapatite.