期刊
FIBROGENESIS & TISSUE REPAIR
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13069-016-0038-0
关键词
Diabetic nephropathy; Dipeptidyl peptidase-4; Kidney protection
类别
资金
- Japan Society for the Promotion of Science [23790381, 25282028, 25670414]
- Japan Research Foundation for Clinical Pharmacology
- Grant for Collaborative Research [C2011-4, C2012-1]
- Kanazawa Medical University [S2011-1, S2012-5]
- Kanazawa Medical University
Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease worldwide and is associated with increased morbidity and mortality in patients with both type 1 and type 2 diabetes. Recent evidence revealed that dipeptidyl peptidase-4 (DPP-4) inhibitors may exhibit a protective effect against DN. In fact, the kidney is the organ where the DPP-4 activity is the highest level per organ weight. A preclinical analysis revealed that DPP-4 inhibitors also ameliorated kidney fibrosis. In this review, we analyzed recent reports in this field and explore the renoprotective effects and possible mechanism of the DPP-4 inhibitors.
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