期刊
BIOTECHNOLOGY ADVANCES
卷 36, 期 4, 页码 915-934出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2018.02.013
关键词
Kinases; Kinomes; Parasitic worms; Bioinformatics; Curation; Biotechnology
资金
- National Health and Medical Research Council of Australia (NHMRC)
- Australian Research Council (ARC), Australia
- Wellcome Trust, UK
- Australian Academy of Science, Australia
- Australian-American Fulbright Commission, Australia
- Alexander von Humboldt Foundation, Germany
- Melbourne Water Corporation, Australia
- Melbourne Bioinformatics Platform, Australia
- WormBase
Protein kinases are enzymes that play essential roles in the regulation of many cellular processes. Despite expansions in the fields of genomics, transcriptomics and bioinformatics, there is limited information on the kinase complements (kinomes) of most eukaryotic organisms, including parasitic worms that cause serious diseases of humans and animals. The biological uniqueness of these worms and the draft status of their genomes pose challenges for the identification and classification of protein kinases using established tools. In this article, we provide an account of kinase biology, the roles of kinases in diseases and their importance as drug targets, and drug discovery efforts in key socioeconomically important parasitic worms. In this context, we summarise methods and resources commonly used for the curation, identification, classification and functional annotation of protein kinase sequences from draft genomes; review recent advances made in the characterisation of the worm kinomes; and discuss the implications of these advances for investigating kinase signalling and developing small-molecule inhibitors as new anti-parasitic drugs.
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