期刊
BIOTECHNOLOGY ADVANCES
卷 36, 期 6, 页码 1608-1621出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2018.04.002
关键词
Atherosclerosis; Drug-discovery; Molecular target; Natural products; Restenosis; Signaling pathway; Vascular smooth muscle cell proliferation
资金
- Homing grant from Foundation for Polish Sciences
- Austrian Science Fund (FWF) project [P25971-B23]
- Ernst Mach Grant - worldwide [ICM-2016-03293]
- Post-doe from KNOW - Healthy Animals - Safe Food [KNOW2017/CB/PDC4/6]
- Polish KNOW (Leading National Research Centre) Scientific Consortium Healthy Animal-Safe Food [05-1/KNOW2/2015]
- Peter and Traudl Engelhorn Foundation for the promotion of Life Sciences
Many natural products have been so far tested regarding their potency to inhibit vascular smooth muscle cell proliferation, a process involved in atherosclerosis, pulmonary hypertension and restenosis. Compounds studied in vitro and in vivo as VSMC proliferation inhibitors include, for example indirubin-3'-monoxime, resveratrol, hyperoside, plumericin, pelargonidin, zerumbone and apamin. Moreover, taxol and rapamycin, the most prominent compounds applied in drug-eluting scents to counteract restenosis, are natural products. Numerous studies show that natural products have proven to yield effective inhibitors of vascular smooth muscle cell proliferation and ongoing research effort might result in the discovery of further clinically relevant compounds.
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